Which of the following statements about protein structure is correct?
A) The alpha-helix conformation is stabilized by hydrophobic interactions.
B) The beta-sheet conformation is rarely found in globular proteins.
C) The folding of a polypeptide into a globular structure results in an interior enriched with hydrophobic amino acids.
D) The primary structure does not influence the native tertiary structure.
E) The subunits of proteins with quaternary structure associate through covalent bonds.

Question

Quizplus · Accepted Answer

When a polypeptide folds into a globular structure, the hydrophobic amino acids tend to be buried in the interior of the protein away from water.

Answer: A
 The alpha-helix conformation is stabilized by hydrogen bonds, not hydrophobic interactions.

Answer: B
 The beta-sheet conformation is common in globular and fibrous proteins.

Answer: D
 The primary structure, or sequence of amino acids, is fundamental in determining the native tertiary structure.

Answer: E
 The subunits of proteins with quaternary structure associate through noncovalent interactions, such as hydrogen bonds and van der Waals forces, rather than covalent bonds.

Which of the Following Statements About Protein Structure Is Correct