Changes in balance between excitation and inhibition account for symptoms in:
A) Tourette syndrome.
B) Parkinson disease.
C) stroke.
D) both Tourette syndrome and Parkinson disease.

Question

Quizplus · Accepted Answer

Tourette syndrome and Parkinson disease both involve alterations in the balance between excitation and inhibition of neural activity. In Tourette syndrome, there is an excess of activity in cortico-striato-thalamo-cortical circuits, leading to tics and other motor and vocal symptoms. In Parkinson disease, there is a reduction in dopamine-mediated excitation of the basal ganglia, leading to bradykinesia, rigidity, and tremors. Both conditions can be treated with medications that modulate the balance between excitation and inhibition in specific neural circuits.

Changes in Balance Between Excitation and Inhibition Account for Symptoms