The Focus on Neuroscience on mapping brain changes in Alzheimer's disease summarized a study that discovered that the disease first attacks the thick bundle of axons called the corpus callosum, which is the main communication link between the two hemispheres.

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Alzheimer's disease typically first affects areas of the brain such as the entorhinal cortex and hippocampus, which are crucial for memory and navigation, before it impacts the corpus callosum.

The Focus on Neuroscience on Mapping Brain Changes in Alzheimer's