Because ob/ob mice produce excessive amounts of leptin, they behave as if they are starving.

Question

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Ob/ob mice have a mutation in the gene that codes for leptin, resulting in a deficiency of leptin hormone. As a result, they become obese, have reduced energy expenditure, and increased food intake due to the lack of signals from leptin that normally suppress appetite and stimulate metabolism. Therefore, they do not behave as if they are starving but rather as if they have unlimited access to food.

Because Ob/ob Mice Produce Excessive Amounts of Leptin, They Behave