Graves disease (hyperthyroidism) is an example of which type II hypersensitivity reaction?
A)Modulation
B)Antibody-dependent cell-mediated cytotoxicity
C)Neutrophil-mediated damage
D)Complement-mediated lysis

Question

Quizplus · Accepted Answer

The antibody reacts with the receptors on the target cell surface and modulates the function of the receptor by preventing interactions with their normal ligands, replacing the ligand and inappropriately stimulating the receptor or destroying the receptor. For example, in the hyperthyroidism (excessive thyroid activity) of Graves disease, autoantibody binds to and activates receptors for thyroid-stimulating hormone (TSH) (a pituitary hormone that controls the production of the hormone thyroxine by the thyroid). Graves disease is not a result of cell-mediated cytotoxicity, neutrophil-mediated damage, or complement-mediated lysis.

Graves Disease (Hyperthyroidism) Is an Example of Which Type II