The patient is placed under general anesthesia for a carotid endarterectomy.During the surgery,the patient develops muscle contracture with skeletal muscle rigidity,acidosis,and elevated temperature.What is a possible cause for malignant hyperthermia?
A) Polymorphism in RYR1 at chromosome 19q13.1
B) Variant in the VKOR1 gene
C) Variant in the cytochrome P450 enzyme CYP2C9 gene
D) Halothane overdose

Question

Quizplus · Accepted Answer

Individuals with polymorphisms in the ryanodine receptor gene (RYR1)at chromosome 19q13.1 are at risk of a rare pharmacogenetic condition known as malignant hyperthermia.In affected individuals,exposure to inhalation anesthetics and depolarizing muscle relaxants during general anesthesia induces life-threatening muscle contracture with skeletal muscle rigidity,acidosis,and elevated temperature.Warfarin is being researched as a variant in the VKOR1 gene and in the cytochrome P450 enzyme CYP2C9 gene.

The Patient Is Placed Under General Anesthesia for a Carotid