Which antibiotic interferes with DNA transcription by blocking of RNA chain elongation?
A)Rifampin
B)Quinolone
C)Trimethoprim
D)Glycopeptide

Question

Quizplus · Accepted Answer

Rifampin, a synthetic derivative of rifamycin B, is used in combination with other antibiotic classes to treat Mycobacterium tuberculosis by targeting transcription of DNA.The target of rifampin in M.tuberculosis is the RNA polymerase b subunit at an allosteric site, with the subsequent blocking of RNA chain elongation.As a result, RNA transcription is aborted at the initiation step.

Which Antibiotic Interferes with DNA Transcription by Blocking of RNA