Which antibiotic affects the DNA replication by targeting topoisomerases II and IV, enzymes considered important in controlling DNA replication?
A)Glycopeptide
B)Sulfamethoxazole
C)Trimethoprim
D)Quinolone

Question

Quizplus · Accepted Answer

Quinolones disrupt the DNA replication cycle of bacteria by targeting topoisomerases II and IV.Interestingly, the targets of quinolones appear to be selective, targeting DNA gyrase in gram-negative bacteria and topoisomerase IV in gram-positive bacteria.However, newer quinolones appear to have high affinity for both targets.

Which Antibiotic Affects the DNA Replication by Targeting Topoisomerases II