A bone marrow transplant may not be appropriate from a given donor (Jane)to a given recipient (Jane's cousin Bob), even though Jane has previously given blood for one of Bob's needed transfusions. Which of the following might account for this?
A)Jane's blood type is a match to Bob's but her MHC proteins are not.
B)A blood type match is less stringent than a match required for transplant because blood is more tolerant of change.
C)For each gene, there is only one blood allele but many tissue alleles.
D)Jane's class II genes are not expressed in bone marrow.
E)Bob's immune response has been made inadequate before he receives the transplant.

Question

Quizplus · Accepted Answer

MHC (major histocompatibility complex) proteins are crucial for identifying foreign antigens and triggering an immune response against them. In bone marrow transplant, it is essential to match not only the blood type but also the MHC proteins to avoid rejection. Even though Jane's blood type is a match for Bob, her MHC proteins may not be, leading to rejection of the transplant.

A Bone Marrow Transplant May Not Be Appropriate from a Given