Defects in NRAMPs cause:
A) Phagosome dysfunction
B) Disruption of protein synthesis
C) Inability to package and release antibodies
D) Defective interactions between CD4 T cells and antigen-presenting cells (APCs)

Question

Quizplus · Accepted Answer

NRAMP1 reduces the pH of the phagosome, which is a key part of bacterial killing. NRAMP2 is an efflux pump that transports iron and other cations out of the phagosome. Defects in these two components lead to ineffective killing in the phagosome, and the bacteria can escape and establish infection inside the macrophage.

Defects in NRAMPs Cause