Which of the following is/are considered a genetic factor that increases susceptibility to mycobacterial infections?
I. Defect in TNF-a receptor
II. Defect in vitamin D receptor
III. Defect in interferon-g receptor
A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Question

Which of the following is/are considered a genetic factor that increases susceptibility to mycobacterial infections? 
I. Defect in TNF-a receptor
II. Defect in vitamin D receptor
III. Defect in interferon-g receptor
A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Quizplus · Accepted Answer

Increased susceptibility to TB infection has been associated with defects in the vitamin D receptor and the interferon-ã receptor. TNF-a causes a significant amount of lung damage in TB, so there is no defect in that receptor.

Which of the Following Is/are Considered a Genetic Factor That