Blocking the actions of which of the following hormones would be expected to lead to the greatest level of appetite suppression?
A) adiponectin
B) ghrelin
C) GLP-1
D) obestatin
E) peptide tyrosine tyrosine, PYY

Question

Quizplus · Accepted Answer

Ghrelin is known as the "hunger hormone" because it stimulates appetite. Blocking ghrelin would likely lead to significant appetite suppression.  Ghrelin is produced and secreted by the X/A-like enteroendocrine cells of the stomach oxyntic (acid secreting) glands. The major effect of ghrelin is exerted within the central nervous system at the level of the arcuate nucleus where it stimulates the release of neuropeptide Y (NPY) and agouti-related protein (AgRP). The actions of NPY and AgRP enhance appetite and, thus, food intake.

Blocking the Actions of Which of the Following Hormones Would