Patients with functional dyspepsia (disturbed indigestion) and prominent nausea frequently experience spurts of excessive acid exposure to the upper duodenum. This results in pancreatic secretion, mainly through the action of which of the following substances?
A) cholecystokinin
B) gastrin
C) glucagon
D) secretin
E) vasoactive intestinal polypeptide

Question

Quizplus · Accepted Answer

Secretin is the hormone primarily responsible for stimulating pancreatic secretion in response to acid in the duodenum. It is released when the duodenum is exposed to acidic chyme, promoting the secretion of bicarbonate-rich pancreatic juice to neutralize the acid.  The strongest stimulator for the release of secretin from cells in the upper small-intestinal mucosa is the contact with acidic chyme. Increased serum secretin levels stimulate water and alkali secretions from the pancreas and the hepatic ducts and inhibit gastrin release. The most potent stimulators for the release of cholecystokinin are not acid but digestion products of fat and protein. Vasoactive intestinal polypeptide does stimulate intestinal and pancreatic secretion but it acts as neurotransmitter in the enteric nervous system and is mainly released by mechanical and neuronal stimulation.

Patients with Functional Dyspepsia (Disturbed Indigestion) and Prominent Nausea Frequently