Which of the following correctly reflects the consequence of insulin binding its receptor in the hypothalamus?
A) activation of melanin-concentrating hormone (MCH) release
B) activation of α-melanocyte stimulating hormone (α-MSH) release
C) activation of neuropeptide Y (NPY) release
D) inhibition of cocaine- and amphetamine-regulated transcript (CART) release
E) inhibition of galanin release

Question

Quizplus · Accepted Answer

Insulin binding in the hypothalamus leads to the activation of α-MSH release, which is involved in reducing appetite and increasing energy expenditure.  Within the brain insulin exerts anorexigenic effects. These effects are responses to insulin binding its receptor on POMC and NPY neurons in the hypothalamus. Insulin-mediated effects include activation of POMC neurons causing release of α-MSH which exerts the anorexigenic effects, and inhibition of NPY neurons, thus blocking the orexigenic effects of NPY.

Which of the Following Correctly Reflects the Consequence of Insulin