Many members of the nuclear family of receptors are prevented from activity through protein-protein interaction. The glucocorticoid receptor, for example, is released from hsp90 (a chaperone protein) following binding by the appropriate steroid hormone. Which of the following represents the next event for the localization of the receptor-hormone complex?
A) cytoplasmic surface of the plasma membrane
B) Golgi cisterna
C) specific DNA sequences
D) specific mRNA transcripts
E) 50S ribosomal subunit

Question

Quizplus · Accepted Answer

The glucocorticoid receptor-hormone complex translocates to the nucleus where it binds to specific DNA sequences to regulate gene expression. The steroid/thyroid hormone receptor superfamily is a class of proteins that reside in the cytoplasm and bind their lipophilic hormone ligands in this compartment as these hormones are capable of freely penetrating the hydrophobic plasma membrane. Upon binding ligand, the hormone-receptor complex translocates to the nucleus and binds to specific DNA sequences termed hormone response elements (HREs). The binding of the complex to an HRE results in altered transcription rates of the associated gene.

Many Members of the Nuclear Family of Receptors Are Prevented