Dopamine transporter knockout mice are hyperactive compared to wild-type mice because
A) they produce more dopamine than wild-type mice.
B) they have fewer receptors than wild-type mice.
C) there is consistent activation of postsynaptic DA receptors.
D) they cannot synthesize dopamine.

Question

Quizplus · Accepted Answer

Dopamine transporter knockout mice are hyperactive because the dopamine transporter, which normally removes dopamine from the synaptic cleft, is absent. This leads to prolonged dopamine action at the synapse and consistent activation of postsynaptic dopamine receptors, contributing to hyperactivity.

Dopamine Transporter Knockout Mice Are Hyperactive Compared to Wild-Type Mice