Changes in which two neurotransmitter systems are most likely involved in the hyperexcitability seen during withdrawal from chronic alcohol?
A) GABA and glutamate
B) GABA and dopamine
C) Dopamine and glutamate
D) The opioids and dopamine

Question

Quizplus · Accepted Answer

Chronic alcohol use leads to downregulation of GABA receptors and upregulation of glutamate receptors. During withdrawal, GABA levels decrease and glutamate levels increase, leading to excessive excitatory activity in the brain.

Changes in Which Two Neurotransmitter Systems Are Most Likely Involved