After withdrawal from chronic alcohol use, an increase in _______ is correlated with an increase in behavioral signs of _______.
A) glutamate release; intoxication
B) glutamate release; withdrawal hyperexcitability
C) receptor inhibition; intoxication
D) receptor inhibition; withdrawal hyperexcitability

Question

Quizplus · Accepted Answer

Chronic alcohol use leads to a decrease in glutamate release, which causes the brain to adapt by downregulating receptors. After alcohol withdrawal, there is an increase in glutamate release, but with fewer receptors available, it leads to hyperexcitability and withdrawal symptoms such as seizures and tremors. Therefore, an increase in glutamate release is correlated with an increase in behavioral signs of withdrawal hyperexcitability.

After Withdrawal from Chronic Alcohol Use, an Increase in _______