The discovery that the intermediate filament protein keratin is essential for mechanical strength of epithelial cell layers was made in
A) cell cultures.
B) organ cultures.
C) small invertebrates.
D) transgenic mice.

Question

Quizplus · Accepted Answer

The discovery that the intermediate filament protein keratin is essential for mechanical strength of epithelial cell layers was made in transgenic mice. This was determined through studies involving mice genetically engineered to lack specific keratin genes, which resulted in the animals exhibiting skin blistering and other defects indicative of compromised epithelial strength.

The Discovery That the Intermediate Filament Protein Keratin Is Essential