Pharmacology for the Primary
Quiz 49 :
D Tardive dyskinesia,or abnormal involuntary movements characterized by rhythmic involuntary movements of the tongue,face,mouth,or jaw,may be progressive and irreversible.This condition can occur with all antipsychotics,especially the first-generation antipsychotics.Increasing the dose may increase the symptoms.Thioridazine is another first-generation antipsychotic with a similar adverse-effect profile.Neuroleptic malignant syndrome occurs weeks after initiation and is characterized by fever,catatonia,muscle rigidity,and autonomic instability.
B First-generation antipsychotics treat positive but not negative symptoms associated with psychotic states.This patient exhibits negative symptoms and should be treated with a second-generation antipsychotic,such as risperidone.The other three drugs are first-generation antipsychotics.
D Before antipsychotic drugs are initiated,baseline laboratory tests,including LFTs,CBC,ECG,and urinalysis,should be performed.Serum lipids and hemoglobin A₁c may be ordered if the patient has risk factors for diabetes or metabolic syndrome.