Which of the following is a major consequence of activation of phospholipase C-β (PLCβ) by the Gq trimeric GTPase?
A) Elevation of intracellular cAMP levels, leading to the activation of protein kinase A
B) Elevation of PIP₃ levels in the plasma membrane, leading to the activation of protein kinase B
C) Elevation of intracellular Ca²⁺ levels, leading to the activation of protein kinase C
D) Elevation of IP₃ in the plasma membrane, leading to the activation of protein kinase D
E) Elevation of intracellular cGMP levels, leading to the activation of protein kinase G

Question

Quizplus · Accepted Answer

Stimulation of protein kinase C (PKC) activity near the plasma membrane results from elevated cytosolic Ca²⁺ [induced by inositol 1,4,5-trisphosphate (IP₃) production] and from binding to diacylglycerol and negatively charged phospholipids. IP₃ and diacylglycerol are second messengers in the cytosol and plasma membrane, respectively, and are produced from phosphatidylinositol 4,5-bisphosphate by the action of PLCβ.

Which of the Following Is a Major Consequence of Activation