Sort the following events to reflect the normal order in which they occur in G-protein-coupled receptor signaling leading to transcription of genes with cAMP response elements. Your answer would be a four-letter string composed of letters A to E only, e.g. ACBD.
(A) Binding of CREB to PKA
(B) Binding of cAMP to PKA
(C) Dissociation of PKA into catalytic and regulatory subunits
(D) Activation of adenylyl cyclase

Question

Sort the following events to reflect the normal order in which they occur in G-protein-coupled receptor signaling leading to transcription of genes with cAMP response elements. Your answer would be a four-letter string composed of letters A to E only, e.g. ACBD.
(A)	Binding of CREB to PKA
(B)	Binding of cAMP to PKA
(C)	Dissociation of PKA into catalytic and regulatory subunits
(D)	Activation of adenylyl cyclase

Quizplus · Accepted Answer

Upon cAMP production by activated adenylyl cyclase, cAMP-dependent protein kinase (PKA) is activated through the release of its catalytic subunits as a result of cAMP binding to the regulatory subunits. The catalytic subunits then enter the nucleus where they phosphorylate CREB (cAMP response element-binding protein), which recruits other proteins to activate transcription of target genes.

Sort the Following Events to Reflect the Normal Order in Which