Indicate whether each of the following descriptions better applies to forward (F) or reverse (R) genetics. Your answer would be a four-letter string composed of letters F and R only, e.g. RFFF.
( ) It involves new gene discovery by genetic screens.
( ) It may also be called genome editing.
( ) In this approach, mutations are introduced deterministically in a known gene.
( ) It is involved in creating knockout mice lacking a particular gene.

Question

Indicate whether each of the following descriptions better applies to forward (F) or reverse (R) genetics. Your answer would be a four-letter string composed of letters F and R only, e.g. RFFF.
( )	It involves new gene discovery by genetic screens.
( )	It may also be called genome editing.
( )	In this approach, mutations are introduced deterministically in a known gene.
( )	It is involved in creating knockout mice lacking a particular gene.

Quizplus · Accepted Answer

Reverse genetics begins with a known gene and mutates it to determine which cell processes require its function. Because the genome of the organism is deliberately altered in a particular way (in gene knockouts, for example), this approach is also called genome engineering or genome editing. New gene discovery through genetic screens and identifying the mutations and the genes responsible for a certain phenotype are examples of the more traditional (forward) approach of classical genetics.

Indicate Whether Each of the Following Descriptions Better Applies to Forward