Question 1

In the adult population, ________ of individuals with acute infectious mononucleosis do not produce heterophile antibodies.

Accepted Answer

10% to 20% of individuals with acute infectious mononucleosis do not produce heterophile antibodies, which are typically detected by the Monospot test.

Question 2

Approximately which percentage of young adults demonstrates antibodies to EBV?

Accepted Answer

A

Question 3

Which of the following stages of infectious mononucleosis infection is characterized by antibody to Epstein-Barr nuclear antigen (EBNA)?

Accepted Answer

Antibody to Epstein-Barr nuclear antigen (EBNA) is typically present during the convalescent period of a past infection and can also be detected during reactivation of a latent infection.

Question 4

Epstein-Barr virus (EBV) is

Accepted Answer

Epstein-Barr virus (EBV) is indeed a DNA herpesvirus, is harbored by B lymphocytes during latent infections, and is considered one of the most ubiquitous viruses known, infecting most people at some point in their lives.

Question 5

A more recent methodology used to detect antibodies to EBNA is

Accepted Answer

ELISA (Enzyme-Linked Immunosorbent Assay) is a more recent and widely used methodology for detecting antibodies, including those against Epstein-Barr Nuclear Antigen (EBNA), due to its sensitivity and specificity.

Question 6

IgM type of heterophile antibodies usually appear during the __________ phase of infectious mononucleosis.

Accepted Answer

IgM type of heterophile antibodies typically appear during the acute phase of infectious mononucleosis, indicating an active infection.

Question 7

All the following statements about Epstein-Barr virus (EBV) are true except that it

Accepted Answer

Epstein-Barr virus (EBV) is indeed an agent in the development of nasopharyngeal carcinoma, making statement D incorrect. EBV is associated with various types of cancer, including Burkitt's lymphoma and nasopharyngeal carcinoma, as well as conditions like infectious mononucleosis, which is typically acute, benign, and self-limiting.

Question 8

The use of horse erythrocytes in rapid slide tests for infectious mononucleosis increases the

Accepted Answer

Horse erythrocytes are used in rapid slide tests for infectious mononucleosis because they increase the readability, sensitivity, and specificity of the test.

Question 9

Match each procedure to the appropriate description.
-Davidsohn differential test

Accepted Answer

The Davidsohn differential test is specifically designed to distinguish between different types of heterophile antibodies. It achieves this by utilizing three different types of cells: beef erythrocytes, guinea pig kidney cells, and sheep erythrocytes. Each type of cell interacts differently with the various heterophile antibodies, allowing for differentiation among them.

Question 10

In rapid MonoSlide testing, a false-positive result can be caused by

Accepted Answer

All the listed options can cause a false-positive result in rapid MonoSlide testing. Observing agglutination after the recommended observation time can lead to incorrect results, as can misinterpreting what is seen. Additionally, residual heterophile antibodies that remain after the clinical symptoms have subsided can also lead to a false-positive result.

Question 11

Immunocompetent individuals maintain EBV as a(n)

Accepted Answer

EBV (Epstein-Barr Virus) is typically maintained as a chronic latent infection in immunocompetent individuals, where the virus remains in the body without causing symptoms.

Question 12

Match each procedure to the appropriate description.
-MonoSlide agglutination test

Accepted Answer

The MonoSlide agglutination test specifically detects heterophile antibodies using horse erythrocytes as the medium for the reaction.

Question 13

A blood transfusion from an immune donor to a nonimmune recipient may produce

Accepted Answer

The answer of A blood transfusion from an immune donor...

Question 14

The MonoSlide test is based on the agglutination of

Accepted Answer

The answer of The MonoSlide test is based on the...

Question 15

EBV is transmitted primarily by

Accepted Answer

EBV (Epstein-Barr Virus) is primarily transmitted through close contact with infectious oropharyngeal secretions, such as saliva, which is why it is often spread through kissing.

Question 16

Viral capsid antigen (VCA) is produced by

Accepted Answer

Viral capsid antigen (VCA) is produced by infected B lymphocytes, particularly in the context of Epstein-Barr virus (EBV) infection.

Question 17

Match each procedure to the appropriate description.
-Paul-Bunnell screening test

Accepted Answer

The Paul-Bunnell screening test is designed to detect heterophile antibodies and uses sheep erythrocytes.

Question 18

EBV is typically manifested by

Accepted Answer

EBV, or Epstein-Barr Virus, is most commonly associated with infectious mononucleosis, which typically manifests in adolescents and young adults, not in very young children, middle-aged individuals, or older adults.

Question 19

In infectious mononucleosis, EBV

Accepted Answer

In infectious mononucleosis, Epstein-Barr Virus (EBV) infects B lymphocytes, leads to the production of atypical lymphocytes in the peripheral blood that have T cell characteristics, and induces a cytotoxic T cell response against the EBV-infected circulating B lymphocytes.

Question 20

Anti-VCA immunoglobulin G (IgG) is usually detectable within

Accepted Answer

Anti-VCA IgG typically becomes detectable 4 to 7 days after the onset of symptoms in infections such as Epstein-Barr virus (EBV).

Quiz 21: Infectious Mononucleosis