Drugs and the Neuroscience

Psychology

Quiz 9 :

Ghb, Inhalants, and Anesthetics

Quiz 9 :

Ghb, Inhalants, and Anesthetics

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At what rate does GHB degrade into GABA in the brain?
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A

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Dr. Arnold studies endogenous GHB production in the brain. What does he determine is the relationship between GHB and GABA?
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B

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Gamma-hydroxybutyrate (GHB) is both a drug and a neurotransmitter that has what type of effects on the central nervous system (CNS)?
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A

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What criminal act is most often associated with GHB use?
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Dan was prosecuted for the illegal synthesis and disruption of GHB. What household item was listed in the court documents as a precursor chemical for GHB synthesis?
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Researchers first synthesized GHB in 1960 as part of an effort to develop compounds that have a similar chemical structure to the neurotransmitter ____.
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Dr. Arnold scours the literature and finds that beyond the GHB receptor, studies indicate that GHB functions as an agonist for the ____ receptor (Diana et al., 1991; Pistis et al., 2005).
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Early pharmacological studies found that GHB elicits a unique sleeping pattern that is characterized by ____.
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Why do authorities often have a difficult time verifying the use of GHB in sexual assault cases?
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The oral delivery of GHB is the most common route of delivery used in sexual assault cases. Why might this be?
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Graduate student Darryl adds DrugX to the bathing media of his neuronal cultures and finds strong depletion of GHB. What was a likely target of this drug?
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Which statement regarding GHB is true?
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Why is the GHB derivative sodium oxybate an effective treatment for narcolepsy?
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Sodium GHB is used for the treatment of ____.
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Dr. Arnold analyzes the results of an experiment exploring the interaction of GHB with its receptor. What is Dr. Arnold likely to find?
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Dr. Arnold performs an immunocytochemical stain to determine the localization of GHB receptors. What is he likely to find?
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In the body, naturally occurring GHB is a metabolite of ____.
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Dr. Arnold is excited to discover the relationship between GHB and dopamine release. What does he find?
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Dr. Arnold studies endogenous GHB production and storage in the brain. He determines that the relationship between GHB and GABA storage is that they are stored ____.
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Dr. Bennett lectures on the function of prodrugs, which are converted to active metabolites in the body. She describes the final step in the conversion of prodrug 1,4-butanediol to GHB. What pathway does she describe?
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