The major advantage of using artificial chromosomes such as YACs and BACs for cloning genes is that
A) plasmids are unable to replicate in cells.
B) only one copy of a plasmid can be present in any given cell, whereas many copies of a YAC or BAC can coexist in a single cell.
C) YACs and BACs can carry much larger DNA fragments than ordinary plasmids can.
D) YACs and BACs can be used to express proteins encoded by inserted genes, but plasmids cannot.
E) All of these are correct.

Question

Quizplus · Accepted Answer

YACs and BACs can carry large DNA fragments that plasmids cannot. This makes YACs and BACs more suitable for cloning larger genes or gene clusters. While the other options listed may also be advantages of using YACs or BACs, they are not necessarily the major advantage.

The Major Advantage of Using Artificial Chromosomes Such as YACs