Which Is More Likely to Be the Case for Gene

Which is more likely to be the case for gene A found at the hub of a genetic network, compared to gene B, in the same network but not in a hub?

A) gene A is a nuclear gene, while gene B is mitochondrial
B) gene A is highly expressed
C) gene A encodes a transcription factor that controls the expression of one gene
D) gene A controls the expression of many genes
E) gene B encodes a protein that interacts with many different proteins