Why does the Hill function use maximum promoter activity as a parameter?
A) Maximum promoter activity is the best predictor of activator concentration.
B) Maximum promoter activity cannot be measured,so it must be represented as a variable.
C) Transcription rate is limited by factors other than activator concentration.
D) Maximum promoter activity is negatively correlated with activator concentration.
E) Transcription rate is by definition maximal in hysteric systems.

Question

Quizplus · Accepted Answer

The Hill function incorporates maximum promoter activity as a parameter because transcription rate is limited by factors other than just the concentration of an activator. This reflects the complexity of transcriptional regulation, where maximum efficiency is constrained by various biological factors, such as the availability of transcriptional machinery, chromatin state, and interaction with other regulatory proteins.

Why Does the Hill Function Use Maximum Promoter Activity as a Parameter