The condition sickle-cell anaemia is due to
A) the insertion of an amino acid.
B) the deletion of an amino acid.
C) substitution of an amino acid.
D) failure to synthesize a haemoglobin molecule.
E) unequal recombination resulting in the deletion of the β chain haemoglobin gene.

Question

Quizplus · Accepted Answer

Sickle-cell anaemia is caused by a single nucleotide substitution, resulting in the replacement of glutamic acid with valine at position six of the beta-globin chain of hemoglobin. This substitution leads to the production of abnormal hemoglobin molecules that can cause red blood cells to become stiff and sickle-shaped, impairing their ability to carry oxygen and causing a range of symptoms.

The Condition Sickle-Cell Anaemia Is Due to