Quiz 15: Cancer Genetics
Q 1Q 1
Considering the clonal evolution of tumors,mutations in which kinds of genes would speed up the rate of mutations? a.structural genes b.metabolism genes c.DNA-repair genes d.nuclear-import genes
DNA - repair genes
Q 2Q 2
Which of the following is true of tumor-suppressor genes? a.Their normal function is to promote cell proliferation. b.Their mutant forms are typically dominant. c.They were the first cancer-causing genes to be identified. d.None of the above is true of tumor-suppressor genes.
None of the above is true of tumor-suppressor genes.
Q 3Q 3
In an experiment you mutate the retinoblastoma gene RBsuch that its gene product behaves as if hyperphosphorylated.The result would be a ______ association between RB and E2F,with _______ transcription of genes necessary for DNA replication. a.stronger; unregulated b.stronger; tightly regulated c.weaker; unregulated d.weaker; tightly regulated
Q 4Q 4
In cancer cells you notice that the chromosomes are not shortening,even after many cell divisions.A mutation in the expression of which gene might lead to this observation? a.DNA-repair genes b.retinoblastoma c.palladin d.telomerase e.ras