Why are BRCA1 and BRCA2 considered to be tumor-suppressor genes?
A) Their normal products participate in repair of DNA damage.
B) The mutant forms of either one of these prevent breast cancer.
C) The normal genes make estrogen receptors.
D) They block penetration of breast cells by chemical carcinogens.

Question

Quizplus · Accepted Answer

BRCA1 and BRCA2 are considered to be tumor-suppressor genes because their normal products participate in repair of DNA damage. Mutations in these genes can result in a loss of DNA repair function, leading to an increased risk of developing certain cancers, particularly breast and ovarian cancers.

Why Are BRCA1 and BRCA2 Considered to Be Tumor-Suppressor Genes