A researcher found a method she could use to manipulate and quantify phosphorylation and methylation in embryonic cells in culture. One of her colleagues suggested she try increased methylation of cytosine (C) nucleotides in the DNA of promoters of a mammalian system. Which of the following results would she most likely see?
A) decreased chromatin condensation
B) activation of histone tails for enzymatic function
C) higher levels of transcription of certain genes
D) inactivation of the selected genes

Question

Quizplus · Accepted Answer

Increased methylation of cytosine nucleotides in the DNA of promoters is associated with gene silencing, or inactivation. Therefore, the most likely result would be inactivation of the selected genes.

A Researcher Found a Method She Could Use to Manipulate