A researcher found a method she could use to manipulate and quantify phosphorylation and methylation in embryonic cells in culture. In one set of experiments, she succeeded in increasing acetylation of histone tails in the chromatin of the cells. Which of the following results would she most likely see in these cells?
A) increased chromatin condensation
B) decreased chromatin condensation
C) decreased binding of transcription factors
D) inactivation of the selected genes

Question

Quizplus · Accepted Answer

Acetylation of histone tails is known to increase the accessibility of the DNA to the transcriptional machinery, thus increasing transcription. This is achieved by decreasing the chromatin condensation, which facilitates access to the DNA by the transcription factors.

A Researcher Found a Method She Could Use to Manipulate