What Property Defines Most Ligands for Intracellular Receptors

What property defines most ligands for intracellular receptors?

A) They are lipid-soluble
B) They are hydrophilic
C) They are molecules that can perform significant hydrogen bonding interactions with water
D) They are large molecules They are mostly lipophilic molecules so that they can penetrate the lipid bilayer and interact with their receptors.