Question 1

The monoclonal marker that is often positive in T-ALL is:

Accepted Answer

CD7 is often positive in T-cell acute lymphoblastic leukemia (T-ALL), serving as a marker for T-cell lineage.

Question 2

Migration to extramedullary sites is a feature of which of the following leukemias?

Accepted Answer

Acute monocytic leukemia (AML-M5) is known for its tendency to migrate to extramedullary sites, such as the gums, skin, and central nervous system.

Question 3

A patient presents with generalized lymphadenopathy and a WBC of 100 $\times$ 10⁹/L.This hematologic picture would most likely be seen in:

Accepted Answer

Chronic lymphocytic leukemia (CLL) is characterized by a high white blood cell count, often exceeding 100 x 10^9/L, and generalized lymphadenopathy. This presentation aligns with the patient's symptoms and lab findings.

Question 4

When performing flow cytometry, the technologist interpreted the flow pattern as exhibiting a high degree of CD14- and CD4-positive cells.The peripheral smear showed large multilobulated blast cells.This pattern is most representative of:

Accepted Answer

AMonoL, or Acute Monoblastic Leukemia, is characterized by the presence of large numbers of monoblasts in the blood. The high degree of CD14- and CD4-positive cells is indicative of monoblastic lineage, as CD14 is a monocyte marker and CD4 can be expressed on monocytes and their precursors. The description of large multilobulated blast cells in the peripheral smear further supports this diagnosis, as these are typical features of monoblasts in Acute Monoblastic Leukemia.

Question 5

The translocation t(15:17)(q22;q12) is associated with which of the following leukemias?

Accepted Answer

The translocation t(15;17)(q22;q12) is specifically associated with acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML), characterized by the presence of promyelocytes in the bone marrow. This genetic abnormality leads to the production of the PML-RARA fusion protein, which plays a key role in the pathogenesis of the disease.

Question 6

The leukemia with a predominance of WBC cells positive for CD41 is:

Accepted Answer

AMegL, or Acute Megakaryoblastic Leukemia, is characterized by a predominance of white blood cells that are positive for CD41, a marker associated with megakaryocytes and platelets.

Question 7

Acute leukemic processes are marked by:

Accepted Answer

Acute leukemic processes are characterized by rapid onset and often present with symptoms such as anemia and thrombocytopenia due to the high turnover of leukemic cells affecting the production of normal blood cells.

Question 8

_____ is predominantly a disease of children.

Accepted Answer

ALL, or Acute Lymphoblastic Leukemia, is predominantly a disease of children, being the most common cancer in children.

Question 9

Greater than ______ of bone marrow cells must be identified as lymphoblasts to meet the WHO definition of ALL.

Accepted Answer

According to the World Health Organization (WHO) definition, more than 20% of bone marrow cells must be identified as lymphoblasts to diagnose Acute Lymphoblastic Leukemia (ALL).

Question 10

The basic pathophysiology mechanism responsible for producing signs and symptoms in leukemia includes all of the following except:

Accepted Answer

The basic pathophysiology of leukemia involves the replacement of normal bone marrow cells with abnormal leukemic cells, leading to a decrease in the production of functional blood cells. This can result in increased infections due to a lack of functional leukocytes, and hemorrhage due to thrombocytopenia (a decrease in platelets). However, decreased erythropoietin production is not a direct mechanism of leukemia; erythropoietin is a hormone produced by the kidneys that influences red blood cell production, and its decrease is not a primary effect of leukemia.

Question 11

Pure erythroid leukemia is defined as:

Accepted Answer

Pure erythroid leukemia is characterized by a predominance of erythroid precursors, specifically greater than 80% of the bone marrow cells, with a significant reduction in myeloblasts.

Question 12

Pediatric patients with ALL have an overall complete remission rate of:

Accepted Answer

Pediatric patients with Acute Lymphoblastic Leukemia (ALL) have an overall complete remission rate of approximately 85%, reflecting significant advancements in treatment protocols.

Question 13

Which CD marker best represents the earliest progenitor cells?

Accepted Answer

CD34 is widely recognized as a marker of early progenitor cells, including hematopoietic and endothelial progenitor cells.

Question 14

A patient with AML is likely to have a cytochemical stain panel that is positive for:

Accepted Answer

MPO (Myeloperoxidase), SBB (Sudan Black B), and specific esterase are cytochemical stains that are typically positive in acute myeloid leukemia (AML), helping to differentiate it from other types of leukemia.

Question 15

Which of the following is characteristic of Auer rods?

Accepted Answer

Auer rods are indeed composed of fused primary granules and are a characteristic feature of certain types of leukemia, particularly acute myeloid leukemia (AML), not ALL (acute lymphoblastic leukemia) or HCL (hairy cell leukemia).

Question 16

According to current WHO classification criteria, acute leukemia is characterized by which of the following?

Accepted Answer

Acute leukemia is characterized by a hypercellular bone marrow with greater than 20% blasts according to the World Health Organization (WHO) classification criteria. This high percentage of blasts is a key feature distinguishing acute leukemia from other hematologic disorders.

Quiz 11: Acute Leukemias

The monoclonal marker that is often positive in T-ALL is:

Migration to extramedullary sites is a feature of which of the following leukemias?

A patient presents with generalized lymphadenopathy and a WBC of 100 $\times$ 10⁹/L.This hematologic picture would most likely be seen in:

When performing flow cytometry, the technologist interpreted the flow pattern as exhibiting a high degree of CD14- and CD4-positive cells.The peripheral smear showed large multilobulated blast cells.This pattern is most representative of:

The translocation t(15:17) (q22;q12) is associated with which of the following leukemias?

The leukemia with a predominance of WBC cells positive for CD41 is:

Acute leukemic processes are marked by:

_____ is predominantly a disease of children.

Greater than ______ of bone marrow cells must be identified as lymphoblasts to meet the WHO definition of ALL.

The basic pathophysiology mechanism responsible for producing signs and symptoms in leukemia includes all of the following except:

Pure erythroid leukemia is defined as:

Pediatric patients with ALL have an overall complete remission rate of:

Which CD marker best represents the earliest progenitor cells?

A patient with AML is likely to have a cytochemical stain panel that is positive for:

Which of the following is characteristic of Auer rods?

According to current WHO classification criteria, acute leukemia is characterized by which of the following?

Quiz 11: Acute Leukemias

The monoclonal marker that is often positive in T-ALL is:

Migration to extramedullary sites is a feature of which of the following leukemias?

A patient presents with generalized lymphadenopathy and a WBC of 100 ×\times× 109/L.This hematologic picture would most likely be seen in:

When performing flow cytometry, the technologist interpreted the flow pattern as exhibiting a high degree of CD14- and CD4-positive cells.The peripheral smear showed large multilobulated blast cells.This pattern is most representative of:

The translocation t(15:17) (q22;q12) is associated with which of the following leukemias?

The leukemia with a predominance of WBC cells positive for CD41 is:

Acute leukemic processes are marked by:

_____ is predominantly a disease of children.

Greater than ______ of bone marrow cells must be identified as lymphoblasts to meet the WHO definition of ALL.

The basic pathophysiology mechanism responsible for producing signs and symptoms in leukemia includes all of the following except:

Pure erythroid leukemia is defined as:

Pediatric patients with ALL have an overall complete remission rate of:

Which CD marker best represents the earliest progenitor cells?

A patient with AML is likely to have a cytochemical stain panel that is positive for:

Which of the following is characteristic of Auer rods?

According to current WHO classification criteria, acute leukemia is characterized by which of the following?

A patient presents with generalized lymphadenopathy and a WBC of 100 $\times$ 10⁹/L.This hematologic picture would most likely be seen in: