Use the following information when answering the corresponding questions) .
A group of enzymes known as cytosine- specific DNA methylases recognize CpG dinucleotide sequences-that is, a cytosine followed by a guanosine G) in one DNA strand-and add methyl groups to the cytosine. Many proteins bind to methylated CpG, including the methyl- CpG binding protein 2 MeCP2) . MeCP2 binding leads to the formation of a closed state of chromatin, thus silencing gene expression. A recent paper by Chen et al. reported an interesting mechanism of regulating transcription of a gene via MeCP2 W. Chen, Q. Chang, Y. Lin, A. Meissner, A. E. West, E. C. Griffith, R. Jaenish, and M. Greenberg. 2004. Derepression of BDNF transcription involves calcium- dependent phosphorylation of MeCP2, Science 302:885-89) . This gene, called BDNF, encodes brain- derived neurotrophic factor BDNF) -a protein that plays an important role in nerve cell and central nervous system function, including memory and learning. Remarkably, most cases of Rett syndrome, an important cause of mental retardation in females, are due to loss- of- function mutations of MeCP2.
-A patient is undergoing genetic screening for cancer. The results show the patient has many proto- oncogenes. Based on this information only, which of the following statements is correct regarding the probability that this patient will develop cancer in the very near future?
A) The chances are low because the patient would have to show an increased number of oncogenes.
B) The chances are high because the patient most likely also shows an increase in the number of tumor suppressors.
C) Due to the increased number of proto- oncogenes, the chances are high.
Correct Answer:
Verified
Q26: Gene expression is often assayed by measuring
Q27: If DNA were inflexible, which of the
Q28: Why can gene expression be altered more
Q29: Use the following information when answering the
Q30: The rate of translation can be slowed
Q32: Which of the following best explains the
Q33: Use the following information when answering the
Q34: Regulatory transcription factors
A) influence the assembly of
Q35: p53 activates genes that
A) arrest the cell
Q36: Which of the following types of mutation
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