Which type of disorder is most difficult to correct by gene therapy?
A) a recessive disorder
B) an incompletely dominant disorder
C) a dominant disorder
D) Disorders showing all these forms of dominance present equal challenges.

Question

Quizplus · Accepted Answer

Dominant disorders are caused by the presence of a single mutated allele, which means that the corrected gene would need to be inserted into every cell in the body to be effective. This presents a significant challenge for gene therapy, as it is difficult to ensure that every cell receives the corrective gene. In contrast, recessive disorders require the insertion of a functional copy of the gene in only some cells, as these cells can produce enough of the missing protein to compensate for the non-functional cells. Incompletely dominant disorders also present a challenge, but the severity of the disorder can vary depending on the level of protein production from the non-mutated allele.

Which Type of Disorder Is Most Difficult to Correct by Gene