Which of the following contributes to the pathogenesis of Bernard-Soulier syndrome?
A) Abnormal glycoprotein Ib/IX complex
B) Abnormal glycoprotein IIb/IIIa
C) High platelet count
D) Low fibrinogen level

Question

Quizplus · Accepted Answer

Bernard-Soulier syndrome is a rare bleeding disorder caused by defects in the glycoprotein Ib/IX complex on the surface of platelets, which is important for platelet adhesion to von Willebrand factor and collagen. Abnormalities in glycoprotein IIb/IIIa are associated with Glanzmann thrombasthenia. High platelet count and low fibrinogen levels are not typically associated with Bernard-Soulier syndrome.

Which of the Following Contributes to the Pathogenesis of Bernard-Soulier