The Principle of In-Solution Hybridization Is

The principle of in-solution hybridization is

A) the hybridization between a labeled probe and target nucleic acids in a liquid solution in tubes or in microtiter wells.
B) the hybridization between an immobilized labeled probe and target nucleic acids in a liquid solution in tubes or in microtiter wells.
C) the hybridization between a labeled probe in solution and immobilized target nucleic acids.
D) when two solutions are combined and hybridization occurs between the probe and the target, then the tube is centrifuged to detect the precipitated hybridized target and probes.