Question 1

Which of the following statements regarding neuronal response in the initiation of an erection is true?

Accepted Answer

The initiation of an erection is primarily a parasympathetic response. This involves the release of nitric oxide (NO) in the blood vessels of the penis, leading to vasodilation and the inflow of blood that causes an erection.

Question 2

Which statement regarding men's health in the United States is true?

Accepted Answer

Research suggests that men may be less likely than women to seek medical care and are more likely to put off routine checkups and ignore symptoms. This can lead to delayed diagnoses and poorer outcomes for certain conditions.

Question 3

Which of the following best describes the duration of effect for tadalafil (Cialis)?

Accepted Answer

Tadalafil, the active ingredient in Cialis, has a duration of effect of up to 36 hours, which is significantly longer than other erectile dysfunction medications like sildenafil (Viagra) or vardenafil (Levitra).

Question 4

The presence of food most significantly inhibits the absorption of which PDE5 inhibitor?

Accepted Answer

The presence of food significantly decreases the absorption of sildenafil, therefore it should be taken on an empty stomach. Tadalafil and vardenafil can be taken with or without food, but a high-fat meal may delay the onset of action. Alprostadil is not a PDE5 inhibitor, it works by relaxing smooth muscle and dilating blood vessels.

Question 5

All of the following are nonselective alpha-one blockers except:

Accepted Answer

Tamsulosin (Flomax) is the only alpha-one blocker in the list that is selective for the alpha-one receptors in the prostate, and does not significantly affect blood pressure. Doxazosin, prazosin, and terazosin are all nonselective alpha-one blockers, meaning that they can cause significant decreases in blood pressure and are also used to manage hypertension.

Question 6

This adverse effect of the alpha blockers requires such medications to be started at the lowest dose.

Accepted Answer

Orthostatic hypotension is a common adverse effect of alpha blockers, which can cause dizziness or fainting upon standing up. Therefore, it is recommended that alpha blockers are started at the lowest dose to minimize this risk. Bleeding, hypersensitivity, and flu-like symptoms are not typically associated with alpha blockers.

Question 7

Which of the following statements regarding BPH treatment with alpha-one blockers is false?

Accepted Answer

Alpha-one blockers can relieve the symptoms of BPH by relaxing smooth muscles in the prostate gland, but they do not actually shrink the size of the prostate.

Question 8

According to the Massachusetts Male Aging Study (MMAS),what percentage of males aged 40 to 70 years has had some degree of ED?

Accepted Answer

The Massachusetts Male Aging Study (MMAS) found that approximately 52% of males aged 40 to 70 years have had some degree of Erectile Dysfunction (ED).

Question 9

What is the role of cyclic guanosine monophosphate (cGMP)in erectile function?

Accepted Answer

cGMP activates a specific protein kinase, leading to smooth muscle relaxation in the blood vessels of the penis. This allows for increased blood flow and results in an erection.

Question 10

Which of the following PDE5 inhibitors is approved at a low dose for daily use?

Accepted Answer

Tadalafil (Cialis) is the only PDE5 inhibitor that is approved at a low daily dose for use in treating erectile dysfunction. Sildenafil (Viagra) and vardenafil (Levitra) are typically used as needed before sexual activity, while alprostadil (Muse) is administered via urethral suppository.

Question 11

Which of the following medications is slow to show effect,requiring up to 6 months to reach maximum benefit,but can shrink the size of the prostate and show benefits in affecting the clinical course and progression of BPH?

Accepted Answer

Dutasteride (Avodart) is a 5-alpha-reductase inhibitor that can take up to 6 months to show its full effect. It works by shrinking the size of the prostate, which can improve urinary symptoms and potentially affect the clinical course and progression of BPH. Alfuzosin (Uroxatral), doxazosin (Cardura), and tamsulosin (Flomax) are alpha-1 blockers that work quickly to relax smooth muscle in the prostate and bladder neck, improving urinary symptoms, but they do not affect the size of the prostate or the clinical course of BPH.

Question 12

Which of the following ED drugs is most selective for PDE5?

Accepted Answer

Tadalafil (Cialis) is the most selective for PDE5 compared to the other ED drugs. It has a longer half-life and is effective for up to 36 hours. Sildenafil (Viagra) and vardenafil (Levitra) are also PDE5 inhibitors but have shorter half-lives. Alprostadil (Muse) is not a PDE5 inhibitor but instead an intracavernosal injection used for ED treatment.

Question 13

The most common adverse effect of PGE1 (Caverject)is:

Accepted Answer

Penile pain or discomfort is the most common adverse effect associated with the use of PGE1 (Caverject). Other possible side effects include hematoma, fibrosis, priapism, and hypotension. However, penile pain or discomfort is the most frequently reported one. Diarrhea, visual and hearing deficits, and hypotension are not typical adverse effects of PGE1.

Question 14

Signs and symptoms of benign prostatic hypertrophy (BPH)include all of the following except:

Accepted Answer

Hematuria is not typically a sign or symptom of BPH. It is important to rule out other potential causes of hematuria, which may indicate a more serious condition such as prostate cancer.

Question 15

Which of the following statements regarding PDE1 (Caverject)medication for ED is true?

Accepted Answer

PDE1 medication for ED, such as Caverject, is injected into the base of the penis prior to intercourse. Option B is incorrect as the duration of effect varies among individuals and can range from 30 minutes to several hours. Option C is partially correct as the onset of action is typically 5 to 20 minutes after injection. Option D is partially correct, as the effectiveness of Caverject ranges from 60% to 85%. Option E is incorrect as Caverject can be effective for neurogenic causes of ED.

Question 16

Medications account for what percentage of ED?

Accepted Answer

Medications account for approximately 25% of ED visits.

Question 17

The 5-alpha reductase inhibitors work by which mechanism?

Accepted Answer

The 5-alpha reductase inhibitors work by inhibiting the conversion of testosterone to dihydrotestosterone (DHT). This reduction in DHT levels can lead to decreased prostate size and improved urinary symptoms in patients with benign prostatic hyperplasia (BPH).

Question 18

Which of the following is a 5-alpha reductase inhibitor used for the treatment of BPH?

Accepted Answer

Dutasteride (Avodart) is a 5-alpha reductase inhibitor used for the treatment of BPH. The other options listed are alpha blockers which work on a different mechanism for the treatment of BPH.

Question 19

Which of the following statements regarding phosphodiesterase type 5 (PDE5)inhibitors and treatment of ED is true?

Accepted Answer

When patients do not respond to PDE5 inhibitors due to cord injury or innervations damage, alprostadil (Caverject) can be used. This is because alprostadil works by directly relaxing the smooth muscle of the penis, rather than relying on the neurological and vascular mechanisms that PDE5 inhibitors target. Priapism is not more common with oral PDE5 inhibitors than alprostadil, insurance companies generally do not cover daily use of PDE5 inhibitors, and nitrates are contraindicated with PDE5 inhibitors as they can cause dangerous drops in blood pressure.

Question 20

The most common cause of vasculogenic ED is:

Accepted Answer

Atherosclerosis, or the hardening and narrowing of arteries, is the most common cause of vasculogenic erectile dysfunction. It can lead to reduced blood flow to the penis, making it difficult to achieve or maintain an erection.

Quiz 21: Drugs Used to Affect Mens Health

Which of the following statements regarding neuronal response in the initiation of an erection is true?

Which statement regarding men's health in the United States is true?

Which of the following best describes the duration of effect for tadalafil (Cialis) ?

The presence of food most significantly inhibits the absorption of which PDE5 inhibitor?

All of the following are nonselective alpha-one blockers except:

This adverse effect of the alpha blockers requires such medications to be started at the lowest dose.

Which of the following statements regarding BPH treatment with alpha-one blockers is false?

According to the Massachusetts Male Aging Study (MMAS) ,what percentage of males aged 40 to 70 years has had some degree of ED?

What is the role of cyclic guanosine monophosphate (cGMP) in erectile function?

Which of the following PDE5 inhibitors is approved at a low dose for daily use?

Which of the following medications is slow to show effect,requiring up to 6 months to reach maximum benefit,but can shrink the size of the prostate and show benefits in affecting the clinical course and progression of BPH?

Which of the following ED drugs is most selective for PDE5?

The most common adverse effect of PGE1 (Caverject) is:

Signs and symptoms of benign prostatic hypertrophy (BPH) include all of the following except:

Which of the following statements regarding PDE1 (Caverject) medication for ED is true?

Medications account for what percentage of ED?

The 5-alpha reductase inhibitors work by which mechanism?

Which of the following is a 5-alpha reductase inhibitor used for the treatment of BPH?

Which of the following statements regarding phosphodiesterase type 5 (PDE5) inhibitors and treatment of ED is true?

The most common cause of vasculogenic ED is: