Both ephrins and cholinergic retinal waves appear to be necessary for normal formation of retinotopic maps in the:
A) superior colliculus.
B) LGN.
C) primary visual cortex.
D) a and b
E) a, b, and c

Question

Quizplus · Accepted Answer

Triple knockout mice lacking ephrin-A2, ephrin-A5, and the F1F1F1S1F1F1F102 subunit of the nicotinic acetylcholinergic receptor exhibit much more severe defects in the superior colliculus and primary visual cortex than the ephrin double knockout mice, indicating that cholinergic retinal waves play a key role in refining the retinotopic maps in these structures. Ephrin expression patterns and experimental manipulation of cholinergic signaling imply that the same is true of the LGN.

Both Ephrins and Cholinergic Retinal Waves Appear to Be Necessary