Which mechanism(s) could contribute to larger brains with more cortical neurons?
A) A longer period of symmetrical cell division, increasing the pool of radial glia
B) More radial glia divisions, increasing the number of intermediate progenitors
C) Outer radial glia (oRGs) in the subventricular zone that self-regenerate and produce more intermediate progenitors
D) Expression of Wnt pathway effector β-catenin
E) All of the above

Question

Quizplus · Accepted Answer

We have experimental evidence for the first three mechanisms, including in vitro human cortical neurogenesis imaging studies. In mice, experimental overexpression of a stable form of β-catenin results in the expansion of the neuroepithelial progenitor pool and overgrowth of the cerebral cortex.

Which Mechanism(s) Could Contribute to Larger Brains with More Cortical