Why did most scientists assume that the bases of DNA should be on the outside of the helix?
A)the bases were easily digested by DNA cutting enzymes
B)the hydrogen bonding between sugar and phosphate would form a helix as well
C)the bases needed to be accessible for replication
D)a single-stranded DNA molecule would not be able to support the bases on the interior
E)the bases were hydrophobic

Question

Why did most scientists assume that the bases of DNA should be on the outside of the helix?  
A)the bases were easily digested by DNA cutting enzymes
B)the hydrogen bonding between sugar and phosphate would form a helix as well
C)the bases needed to be accessible for replication
D)a single-stranded DNA molecule would not be able to support the bases on the interior
E)the bases were hydrophobic

Quizplus · Accepted Answer

Most scientists initially thought that the bases needed to be accessible for replication and other cellular processes, which led them to assume that the bases should be on the outside of the helix.

Why Did Most Scientists Assume That the Bases of DNA