If a mutation occurred in the cadherin gene so that the cytoplasmic domain no longer attached to the cytoskeleton, which of the following would occur?
A)Cadherins in desmosomes would no longer be anchored to intermediate filaments.
B)Cadherins in adherens junctions would no longer be anchored to microtubules.
C)Cadherins in hemidesmosomes would no longer be anchored to intermediate filaments.
D)Cadherins in desmosomes would no longer be anchored to microfilaments.

Question

Quizplus · Accepted Answer

Cadherins are primarily involved in adherens junctions, where they connect to actin filaments through their cytoplasmic domain, not in desmosomes, which are linked to intermediate filaments through different proteins like desmogleins and desmocollins. The question's premise is slightly misleading because cadherins are not typically associated with desmosomes or hemidesmosomes. However, given the options, A is the closest to a plausible scenario if we consider the general idea of cadherins being unable to anchor to their cytoskeletal connections, despite the specific details being incorrect.

If a Mutation Occurred in the Cadherin Gene So That