Which of the following statements is TRUE regarding the development of pyrimethamine resistance in malaria parasites?
A)Rare mutations in the target protein increased the level of resistance.
B)Continued use of pyrimethamine treatment caused these mutations to increase in frequency.
C)In time, multiple different mutations were brought together to increase the level of resistance.
D)Eventually the drug pyrimethamine became ineffective against malaria.
E)All of these choices are correct.

Question

Quizplus · Accepted Answer

All the statements provided are true regarding the development of pyrimethamine resistance in malaria parasites. Rare mutations in the target protein can confer resistance, and the continued use of pyrimethamine selects for these mutations, increasing their frequency in the parasite population. Over time, multiple mutations can accumulate, further increasing resistance levels, eventually rendering the drug ineffective against malaria.

Which of the Following Statements Is TRUE Regarding the Development