What is the very FIRST effect of ligand binding to a G protein-coupled receptor?
A)the activation of an effector protein
B)the release of the alpha subunit of the G protein
C)a conformational change in the cytoplasmic domain of the receptor
D)an exchange of GTP in place of GDP on the alpha subunit of the G protein

Question

Quizplus · Accepted Answer

The binding of a ligand to G protein-coupled receptor induces a conformational change in the cytoplasmic domain of the receptor, which enables it to interact with the G protein. This is the first step in the activation of the G protein signaling pathway.

What Is the Very FIRST Effect of Ligand Binding to a G