Protein kinase C is allosterically regulated by which second messengers? A) inositol triphosphate (IP₃) B) diacylglycerol (DAG) C) calcium (Ca²⁺) D) both diacylglycerol (DAG) and calcium (Ca²⁺) E) both inositol triphosphate (IP₃) and diacylglycerol (DAG)

Question

Quizplus · Accepted Answer

Protein kinase C is allosterically regulated by both diacylglycerol (DAG) and calcium (Ca2+). These two molecules bind to separate domains on the enzyme, leading to its activation. Inositol triphosphate (IP3) is not an allosteric regulator of protein kinase C, but rather it activates receptors on the endoplasmic reticulum to release stored calcium ions, which in turn can activate protein kinase C.

Protein Kinase C Is Allosterically Regulated by Which Second Messengers