Which Statement Regarding Redox Reactions Is TRUE

Which statement regarding redox reactions is TRUE?

A) NADH and FADH₂ are major electron acceptors in the oxidation of fuel molecules.
B) In glycolysis, the conversion of 2-phosphpoglycerate to phosphoenolpyruvate is a redox reaction.
C) In a redox reaction, the oxidation state of the substrate remains unchanged.
D) A redox reaction is spontaneous when the substrate has a greater reduction potential than the product.
E) The Nerst equation relates the standard reduction potential of a redox pair to its actual reduction potential at any concentration of either the oxidized or reduced form of the species.