Which statement is FALSE regarding transcription at RNA polymerase II promoters?
A) Transcription requires binding of TBP to the -10 promoter element.
B) TFIIB binds TBP and recruits TFIIF that directs RNA polymerase II to the promoter.
C) TFIIH unwinds the DNA and phosphorylates the CTD of RNA polymerase II.
D) TFIIH subunits contribute to a nucleotide-excision repair process.
E) During the elongation phase, elongation factors suppress RNA polymerase II pausing and coordinate protein-protein interactions.

Question

Quizplus · Accepted Answer

This statement is false because TBP actually binds to the TATA box element, which is typically located around -30 to -25 in the promoter region. The -10 element is recognized by another transcription factor called sigma factor in prokaryotes, but not in eukaryotes.

Which Statement Is FALSE Regarding Transcription at RNA Polymerase II