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In a Classic Experiment by Christian Anfinsen in the 1950s

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In a classic experiment by Christian Anfinsen in the 1950s, it was shown that ribonuclease A could be denatured and then refolded into a catalytically active protein. What control experiment demonstrated that ribonuclease A did not need a chaperone to become properly folded?

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In the classic experiment by Christian A...

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